USA; 'Dr McMunn's Elixir of Opium', sold in the United States as a 'denarcotized' nostrum for many ills from c. 1835, it was in fact highly addictive

First formulated in the mid 1830s by Dr John B McMunn (or M’Munn), it became a big hit in the US once a drug company called A B Sands bought the recipe in 1841. The dosage instructions gave plenty of room for manoeuvre:

To a child a month old, or younger, give from half a drop to two drops; to a child 6 months old, from 3 to 10 drops; and to adults from 10 to 60 drops (or even double or treble that much, if the pain and other symptoms be severe and urgent) mixed in two or three teaspoonsfuls of water, according to the size of the dose. As the administration of every medicine should be governed by its effects, it is proper to begin with the smallest dose, and increase or repeat it at proper intervals until the desired effects are produced.

In 1864 the original recipe came to light, showing the process of treating opium with sulphuric ether to remove the narcotine and make the product safe – a nice idea but narcotine doesn’t have narcotic properties anyway, and the medicine certainly was not safe. It was as addictive as any other opium product – in the early 20th century, for example, George Pettey M.D. related the case of a woman who had taken the Elixir for 31 years, losing 16 newborn babies to the congenital effects.

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