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Thailand: An ethnic Karen from northern Thailand playing a 'khaen', or Lao flute, c. 1900.

The Karen are a major ethnic group of Burma, though several hundred thousand live in northern Thailand. Linguistically Tibeto-Burman, the Karen maintain a legend that dates them back to the Gobi Desert of Mongolia. There are several branches of Karen—the Red Karen (Karenni), Sgaw Karen and Pwo Karen. There is also the hilltribe of Padaung, better known as 'Long-neck Karen'. In present-day Myanmar, the Karen rebel army, the KNU, has continuously fought a bloody civil war with the central Burman government since 1948.

The main traditional Lao instrument is the flute-like khene (kaen) which is made of bamboo. The khene (also spelled khaen, kaen and khen) is a mouth organ of Lao origin whose pipes, which are usually made of bamboo, are connected with a small, hollowed-out hardwood reservoir into which air is blown, creating a sound similar to that of the violin.

Today associated with the Lao of Laos and Northeast Thailand, similar instruments date back to the Bronze Age of Southeast Asia. In Cambodia, it is used among the ethnic Lao population of the province of Stung Treng and is used in lakhon ken, a Cambodian dance drama genre that features the khene as the premiere instrument.